You are cordially invited to participate in and attend the 2008 High Performance Computing & Simulation Conference to be held in Nicosia, Cyprus, June 3-6, 2008 in conjunction with the 22nd European Conference on Modeling and Simulation (ECMS 2008). The conference is to address, explore and exchange information on the state-of-the-art in high performance and large scale computing systems, their modeling and simulation, design and use, and their impact. Participation is extended to researchers, designers, educators and interested parties in all related disciplines and specialties.